Detlev Drenckhahn
Institut für Anatomie und Zellbiologie Koellikerstr. 6 D-97070 Würzburg Tel. +49 931 31 82702 Fax +49 931 31 82712 |
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Forschungsbereiche: |
| Organisation und Funktion von Zytoskelett-Membranwechselwirkungen.
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Aktuelle Projekte: |
| Molekulare Regulation der Hautbarriere (Epidermis) und der Blutgefäßdurchlässigkeit (Permeabilität) |
Lehre: |
| Mikroskopisch-anatomisches Praktikum (SS) |
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| Beruflicher Werdegang: |
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| Auslandsaufenthalte: |
Herausgeberschaften: |
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Mitgliedschaften: |
| Ehrenmitglied der Humboldt-Universität zu Berlin |
Persönliche Interessen: |
| Ornithologie |
Interessante Links: |
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Histochemistry and Cell Biology
Ausgewählte Publikationen (2000 bis 2008):
Heupel WM, Zillikens D, Drenckhahn D, Waschke J.
Pemphigus vulgaris IgG directly inhibit desmoglein 3-mediated transinteraction.
J Immunol. 2008 Aug 1;181(3):1825-34.
Förster C, Burek M, Romero IA, Weksler B, Couraud PO, Drenckhahn D.
Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier.
J Physiol. 2008 Apr 1;586(7):1937-49
Baumgartner W, Wendeler MW, Weth A, Koob R, Drenckhahn D, Gessner R.
Heterotypic trans-interaction of LI- and E-cadherin and their localization in plasmalemmal microdomains.
J Mol Biol. 2008 Apr 18;378(1):44-54
Blecharz KG, Drenckhahn D, Förster CY.
Glucocorticoids increase VE-cadherin expression and cause cytoskeletal rearrangements in murine brain endothelial cEND cells.
J Cereb Blood Flow Metab. 2008 Jun;28(6):1139-49
Heupel WM, Baumgartner W, Laymann B, Drenckhahn D, Golenhofen N.
Different Ca2+ affinities and functional implications of the two synaptic adhesion molecules cadherin-11 and N-cadherin.
Mol Cell Neurosci. 2008 Mar;37(3):548-58
Müller-Marschhausen K, Waschke J, Drenckhahn D.
Physiological hydrostatic pressure protects endothelial monolayer integrity.
Am J Physiol Cell Physiol. 2008 Jan;294(1):C324-32
Waschke J, Menendez-Castro C, Bruggeman P, Koob R, Amagai M, Gruber HJ, Drenckhahn D, Baumgartner W.
Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction.
J Membr Biol. 2007 Apr;216(2-3):83-92
Spindler V, Drenckhahn D, Zillikens D, Waschke J.
Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.
Am J Pathol. 2007 Sep;171(3):906-16
Förster C, Kahles T, Kietz S, Drenckhahn D.
Dexamethasone induces the expression of metalloproteinase inhibitor TIMP-1 in the murine cerebral vascular endothelial cell line cEND.
J Physiol. 2007 May 1;580(Pt.3):937-49.
Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D.: Inhibition of Rho A activity causes pemphigus skin blistering.
J Cell Biol. 175(5):721-7. (2006)
Foerster, C., Waschke, J., Burek, M., Leers, J., Drenckhahn, D.: Glucocorticoid effects on microvascular endothelial barrier permeability are brain specific.
J Physiol. 573(Pt 2):413-25. (2006)
Waschke, J., Bruggeman, P., Baumgartner, W., Zillikens, D., Drenckhahn, D: Pemphigus foliaceus IgG causes dissociation of desmoglein 1-containing junctions without blocking desmoglein 1 transinteraction.
J. Clin. Invest. 115, 3157-3165 (2005)
Förster, C., Silwedel, C., Golenhofen, N., Burek, M., Kietz, S., Mankertz, J., Drenckhahn, D.: Occludin as direct target for glucocorticoid-induced improvement of blood brain-barrier properties.
J. Physiol. 565, 475-486 (2005)
Waschke J, Drenckhahn D, Adamson RH, Curry FE.
Role of adhesion and contraction in Rac 1-regulated endothelial barrier function in vivo and in vitro.
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H704-11
Waschke J, Baumgartner W, Adamson RH, Zeng M, Aktories K, Barth H, Wilde C, Curry FE, Drenckhahn D.
Requirement of Rac activity for maintenance of capillary endothelial barrier properties.
Am J Physiol Heart Circ Physiol. 2004 Jan;286(1):H394-401
Baumgartner, W., Wiegand, J., Schütz, G. J., Golenhofen, N., Drenckhahn, D.: Cadherin function probed by laser tweezer and single molecule fluorescence in vascular endothelial cells.
J. Cell Sci. 116, 1001-1011 (2003)
Baumgartner, W., Golenhofen, N., Grundhöfer, N., Wiegand, J., Drenckhahn, D.: Ca2+ dependency of N-cadherin function probed by laser tweezer and atomic force microscopy.
J. Neurosci. 23, 11008-11014 (2003)
Golenhofen N, Arbeiter A, Koob R, Drenckhahn D.
Ischemia-induced association of the stress protein alpha B-crystallin with I-band portion of cardiac titin.
J Mol Cell Cardiol. 2002 Mar;34(3):309-19.
Baumgartner W.; Drenckhahn D. Transmembrane cooperative linkage in cellular adhesion.
Eur. J. Cell Biol, (2002). 81, 161-168
Adamson RH, Curry FE, Adamson G, Liu B, Jiang Y, Aktories K, Barth H, Daigeler A, Golenhofen N, Ness W, Drenckhahn D.
Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice.
J Physiol. 2002 Feb 15;539(Pt 1):295-308.
Hübner S, Jans DA, Drenckhahn D.: Roles of cytoskeletal and junctional plaque proteins in nuclear signaling.
Int Rev Cytol. (2001) 208:207-65
Baumgartner, W., Hinterdorfer, P., Ness, W., Raab, A., Vestweber, D., Schindler, H., Drenckhahn, D.: Cadherin interaction probed by atomic force microscopy.
Proc. Natl. Acad. Sci. USA (2000) 97: 4005-4010
Ausgewählte Publikationen von 1980-1999:
Kraemer, J., Schmitz, F., Drenckhahn, D.: Cytoplasmic dynein and dynactin as likely candidates for microtubule-dependent apical targeting of pancreatic zymogen granules.
Eur. J. Cell Biol. 78, 265-277 (1999)
Höfer, D., Ness, W., Drenckhahn, D.: Sorting of actin isoforms in chicken auditory hair cells.
J. Cell Sci. 110, 765-770 (1997)
Höfer, D., Püschel, B., Drenckhahn, D.: Taste receptor-like cells in the gut identified by expression of alpha-gustducin.
Proc. Nat. Acad. Sci. USA 93, 6631-6634 (1996)
Schmitz, F., Bechmann, M., Drenckhahn, D.: Purification of synaptic ribbons, structural components of the photoreceptor active zone complex.
J. Neurosci. 16(22), 7109-7116 (1996)
Nehls, V., Drenckhahn, D.: A microcarrier-based cocultivation system for the investigation of angiogenesis in a three-dimensional fibrin matrices in vitro.
Histochem. Cell Biol. 104, 459-466 (1995)
Alper, S.L., Stuart-Tilley, A., Simmons, C.F., Brown, D., Drenckhahn, D.: The fodrin-ankyrin cytoskeleton of choroid plexus preferentially colocalizes with apical Na+, K+-ATPase rather than with basolateral anion exchanger AE2.
J. Clin. Invest. 93, 1430-1438 (1994)
Kugler, P., Drenckhahn, D.: Intrinsic source of stomach NO.
Nature 370, 25-26 (1994)
Jöns, T., Drenckhahn, D.: Identification of the binding interface involved in linkage of cytoskeletal protein to the erythrocyte anion exchanger.
EMBO J. 11, 2863-2867 (1992)
Drenckhahn, D., Engel E., Höfer, D., Merte, C., Tilney, M., Tilney, L.: Three different actin filament assemblis occur in every hair cell: Each contains a specific actin cross linking protein.
J. Cell Biol. 112, 641-651 (1991)
Nehls, V., Drenckhahn, D.: Heterogeneity of microvascular pericytes for smooth muscle alpha-actin.
J. Cell Biol. 113, 147-154 (1991)
Schnittler, H., Wilke, A., Gress, T., Suttorp, N., Drenckhahn, D.: Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium.
J. Physiol. 431, 379-401 (1990)
Kraemer, D., Koob, R., Friedrichs, B., Drenckhahn, D.: Two novel peripheral membrane proteins, pasin 1 and pasin 2, associated with Na+,K+-ATPase in various tissues.
J. Cell Biol. 111, 2375-2383 (1990)
Drenckhahn, D., Dermietzel, R.: Organization of the actin filament cytoskeleton in the intestinal brush border: A quantitative and qualitative immunoelectron microscope study.
J. Cell Biol. 107, 1037-1048 (1988)
Drenckhahn, D., Franke, R.-P.: Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man.
Lab. Invest. 59, 673-682 (1988)
Koob, R., Zimmermann, M., Schoner, W., Drenckhahn, D.: Colocalization and coprecipitation of ankyrin and Na+,K+-ATPase in kidney epithelial cells.
Eur. J. Cell Biol. 45, 230-237 (1987)
Wagner S., Vogel, R., Lietzke, R., Koob, R., Drenckhahn, D.: Immunochemical characterization of a band 3-like anion exchanger in the collecting duct of the human kidney.
Am. J. Physiol. 253, F213-D221 (1987)
Schlüter, K., Drenckhahn, D.: Co-clustering of denatured hemoglobin with band 3: Its role in binding of autoantibodies against band 3 to abnormal and aged red blood cells.
Proc. Natl. Acad. Sci. USA 83, 6137-6141 (1986)
Drenckhahn, D., Pollard, T.D.: Elongation of actin filaments is a diffusion-limited reaction at the barbed end and is accelerated by inert molecules.
J. Biol. Chem. 261, 12754-12758 (1986)
Drenckhahn, D., Franz, H.: Identification of actin, alpha-actinin, and vinculin-containing plaques at the lateral membrane of epithelial cells.
J. Cell Biol. 102, 1943-1952 (1986)
Drenckhahn, D., Wagner, H.J.: Stress fibres in the splenic sinus endothelium in situ: Molecular structure, relationship to the extracellular matrix, contractility.
J. Cell Biol. 102, 1738-1747 (1986)
Drenckhahn, D., Schlüter, K., Allen, D.P., Bennett, V.: Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney.
Science 230, 1281-1289 (1985)
Low, P.S., Waugh, S.M., Zinke, K., Drenckhahn, D.: The role of hemoglobin denaturation and band 3 clustering in red blood cell aging.
Science 227, 531-533 (1985)
Franke, R.-P., Gräfe, M., Schnittler, H., Seiffge, D., Mittermayer, C., Drenckhahn, D.: Induction of human vascular endothelial stress fibres by fluid shear stress.
Nature 307, 648-649 (1984)
Drenckhahn, D., Kellner, J., Mannherz, H.G., Gröschel- Stewart, U., Kendrick-Jones, J., Scholey, J.: Absence of myosin-like immunoreactivity in stereocilia of cochlear hair cells.
Nature 300, 531-532 (1982)
Drenckhahn, D., Gröschel-Stewart, U.: Localization of myosin, actin, and tropomyosin in rat intestinal epithelium. Immunocytochemical studies at the light- and electron microscopic levels.
J. Cell Biol. 86, 475-482 (1980)
